Table 5.

Incidence of rejection by time interval

Classes of BiopsiesNumber of Biopsies in Each Interval (Percentage of Total for Interval)Total
EarlyIntermediate: 1–5 yr (366–1825 d)Late
0–7 d8 d to 6 mo (8–180 d)6–12 mo (181–365 d)5–10 yr (1826–3650 d)>10 yr (>3650 d)
n1621369190105110703
Biopsies of kidneys that progressed to failure1 (6)18 (8)9 (13)62 (33)33 (31)45 (41)168
Biopsies with rejection
 Conventional pure TCMR1 (6)41 (19)11 (16)10 (5)3 (3)1 (1)a67
 Molecular pure TCMRb1 (6)42 (20)15 (22)18 (9)0 (0)0 (0)76
 Conventional pure ABMR2 (13)5 (2)2 (3)44 (23)29 (28)28 (25)110
 Molecular pure ABMR0 (0)7 (3)c3 (4)c41 (22)39 (37)34 (31)124
 Conventional mixed0 (0)2 (1)1 (1)11 (6)11 (10)3 (3)d28
 Molecular mixed0 (0)5 (2)6 (9)11 (6)5 (5)1 (1)d28
  • a One conventional pure TCMR at day 3878 (with heavy scarring that may have obscured ABMR lesions) and two conventional mixed at days 4445 and 5989 were considered to have TCMR activity caused by isolated v lesions, which may be because of pure ABMR. All had negative TCMR scores and positive ABMR scores.

  • b Positive TCMR score>0.1; positive ABMR score>0.2.

  • c Some positive ABMR scores before 1 year occurred in biopsies from patients who were donor-specific HLA antibody-negative with no conventional evidence of ABMR activity and may reflect ABMR-like molecular changes in other diseases.

  • d One biopsy at 3717 days (10.2 years) with conventional and molecular mixed rejection was the last with a positive TCMR score.