Table 3.

Association of urine PIIINP with CKD progression in community-living older adult participants in the CHS

Urine PIIINP QuartilesUrine PIIINP Continuous
(Per Doubling)
1234
Urine PIIINP range (μg/L)≤1.391.40–2.582.59–4.22>4.22
No.1051229799
No. with CKD progression,a n (%)40 (38)56 (46)45 (46)51 (52)
Demographic adjusted,b OR (95% CI)1.00 (reference)1.60 (0.92 to 2.80)1.92 (0.99 to 3.69)2.64 (1.28 to 5.46)1.35 (1.11 to 1.63)
Plus eGFR and urine albumin,c OR (95% CI)1.00 (reference)1.34 (0.76 to 2.36)1.40 (0.71 to 2.78)1.68 (0.78 to 3.64)1.23 (1.02 to 1.50)
Plus CVD risk factors,d OR (95% CI)1.00 (reference)1.33 (0.74 to 2.40)1.43 (0.70 to 2.93)1.69 (0.75 to 3.80)1.22 (1.00 to 1.49)
  • OR, odds ratio.

  • a CKD progression defined as ≥30% decline in eGFR at follow-up.

  • b Adjusted for age, sex, race, education, clinic site, and urine creatinine.

  • c Adjusted for demographic variable plus baseline eGFR and urine albumin.

  • d Adjusted for demographic variables eGFR, urine albumin, plus smoking status, pack years, body mass index, diabetes, systolic blood pressure, blood pressure medication use, total cholesterol, lipid medication use, and C-reactive protein.