Table 1.

Baseline characteristics by quartiles of urine PIIINP in 958 randomly selected subcohort participants in the CHS

CharacteristicUrine PIIINP Quartiles
1234
Range (μg/L)≤1.39>1.39–2.58>2.58–4.22>4.22
n240239240239
Demographics
 Age±SD, y78±578±578±579±5
 Male, n (%)60 (25.0)81 (33.9)92 (38.3)145 (60.7)
 Black, n (%)29 (12.1)27 (11.3)41 (17.1)49 (20.5)
 Education (>high school), n (%)83 (34.6)98 (41.0)81 (33.8)90 (37.7)
Lifestyle factors
 Current smoking, n (%)18 (7.5)12 (5.0)23 (9.6)19 (7.9)
 Alcohol (≥7 drinks/wk), n (%)28 (11.7)37 (15.5)34 (14.2)20 (8.5)
Prevalent CVD
 History of MI, n (%)29 (12.1)31 (13.0)23 (9.6)36 (15.1)
 History of HF, n (%)23 (9.6)24 (10.0)13 (5.4)26 (10.9)
 History of stroke, n (%)11 (4.6)15 (6.3)7 (2.9)32 (13.4)
Cardiovascular risk factors
 BMI±SD (kg/m2)26.1±4.426.6±4.827.6±5.027.2±4.6
 SBP±SD (mmHg)137.6±21.1137.6±22.3136.0±20.3136.1±19.7
 DBP±SD (mmHg) 69.2±10.069.8±12.469.3±10.870.4±11.4
 BP medication use, n (%)128 (53.3)141 (59.0)136 (56.7)126 (52.7)
 Diabetes, n (%)20 (8.3)23 (9.6)39 (16.3)51 (21.5)
 Total Chol.±SD (mg/dl)204.6±36.6198.6±38.8205.9±37.6196.5±41.7
 Lipid medication use, n (%)32 (13.3)30 (12.6)27 (11.3)26 (10.9)
 CRP (mg/L), median (IQR)2.3 (1.0–5.1)1.9 (0.9–3.9)2.7 (1.1–5.4)2.5 (1.3–6.4)
 Plasma PIIINP±SD (μg/L)4.4±1.44.7±1.64.8±1.45.2±1.9
Kidney function measures
 Baseline eGFR±SD (ml/min per 1.73 m2)
  In all participants (n=958)67.2±16.065.3±17.763.0±18.358.5±20.4
  In those with follow-up eGFR data (n=289)69.7±15.369.0±17.065.8±16.668.7±19.4
 Follow-up eGFR±SD (ml/min per 1.73 m2) (n=289)64.6±18.560.4±20.458.5±20.659.3±22.5
 Urine ACR, mg/g (IQR)6.4 (3.9–13.6)8.0 (4.7–16.6)7.5 (4.7–18.2)12.3 (7.0–52.6)
  • BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; BP, blood pressure; Chol., cholesterol; CRP, C-reactive protein; IQR, interquartile range.