Table 5.

Association of urine PIIINP with incident CVD, heart failure, and mortality in community-living older adult participants in the CHS

Urine PIIINP QuartilesUrine PIIINP Continuous
Per SD (3.0 μg/L)
1234
Urine PIIINP range (μg/L)≤1.391.40–2.582.59–4.22> 4.22
Incident CVDa
 No. of events75648268
 No. at risk204198212177
 Incidence rate (per 1000 person years)39.133.844.348.0
 Demographic adjusted,b HR (95% CI)1.00 (reference)0.87 (0.62 to 1.23)1.19 (0.83 to 1.71)1.18 (0.78 to 1.78)1.13 (0.97 to 1.31)
 Fully adjusted,c HR (95% CI)1.00 (reference)0.77 (0.54 to 1.09)0.90 (0.61 to 1.33)0.84 (0.54 to 1.32)1.00 (0.85 to 1.18)
Incident HFd
 No. of events60636869
 No. at risk217215227213
 Incidence rate (per 1000 person years)28.330.833.841.7
 Demographic adjusted,b HR (95% CI)1.00 (reference)1.13 (0.78 to 1.62)1.28 (0.86 to 1.89)1.44 (0.94 to 2.21)1.12 (0.96 to 1.32)
 Fully adjusted,c HR (95% CI)1.00 (reference)0.83 (0.57 to 1.21)0.79 (0.52 to 1.20)0.75 (0.47 to 1.19)0.90 (0.75 to 1.08)
Death
 No. of events163166165200
 No. at risk240239240239
 Incidence rate (per 1000 person years)65.968.370.4100.2
 Demographic adjusted,b HR (95% CI)1.00 (reference)1.11 (0.89 to 1.38)1.34 (1.05 to 1.72)1.87 (1.44 to 2.43)1.29 (1.19 to 1.40)
 Fully adjusted,c HR (95% CI)1.00 (reference)0.93 (0.74 to 1.18)1.04 (0.80 to 1.34)1.30 (0.98 to 1.74)1.12 (1.03 to 1.23)
  • a Incident CVD defined as incident MI, stroke, or CVD death. Persons with prevalent CVD at baseline (n=167) were excluded.

  • b Adjusted for age, sex, race, education, clinic site and urine creatinine.

  • c Adjusted for age, sex, race, education, clinical site, urine creatinine, eGFR, urine albumin, smoking status, pack years, body mass index, diabetes, systolic blood pressure, blood pressure medication use, total cholesterol, lipid medication use, and C-reactive protein.

  • d Persons with prevalent HF at baseline (n=86) were excluded.