Table 4.

Associations between age, gender, diabetes and kidney function, and all-cause and cause-specific death in non–dialysis-dependent kidney disease

Number of eventsHR (95% CI) adjusteda
Age >65 years (n=29,501) versus <65 years (n=9019)
All-cause mortalityb66611.73 (1.60 to 1.87)
Deaths due to cardiovascular disease23112.45 (2.10 to 2.86)
Deaths due to malignancy21171.31 (1.15 to 1.48)
Non-cardiovascular/non-malignancy deathc21181.86 (1.62 to 2.14)
Males (n=16,818) versus females (n=21,702)
All-cause mortalityb66611.48 (1.41 to 1.56)
Deaths due to cardiovascular disease23111.56 (1.43 to 1.71)
Deaths due to malignancy21171.51 (1.38 to 1.65)
Non-cardiovascular/non-malignancy deathc21181.39 (1.27 to 1.53)
Patients with diabetes (n=8385) versus non-patients with diabetes (n=30,135)
All-cause mortalityb66611.03 (0.96 to 1.10)
Deaths due to cardiovascular disease23111.01 (0.90 to 1.13)
Deaths due to malignancy21170.80 (0.70 to 0.92)
Non-cardiovascular/non-malignancy deathsc21181.36 (1.21 to 1.53)
CKD Stage 3b (n=10,186) versus Stage 3a (n=24,639)
All-cause mortalityb55691.21 (1.14 to 1.27)
Deaths due to cardiovascular disease18791.35 (1.23 to 1.48
Deaths due to malignancy18981.03 (0.93 to 1.14)
Non-cardiovascular/non-malignancy deathsc16971.29 (1.17 to 1.42)
CKD Stages 4 and 5 (n=3695) versus Stage 3a (n=24,639)
All-cause mortalityb44001.58 (1.46 to 1.70)
Deaths due to cardiovascular disease14491.85 (1.64 to 2.09)
Deaths due to malignancy15011.00 (0.86 to 1.16)
Non-cardiovascular/non-malignancy deathsc13721.93 (1.71 to 2.18)
  • a Model includes age, race gender, diabetes, hypertension, hyperlipidemia, BMI group, albumin and hemoglobin, malignancy, coronary artery disease, congestive heart failure, insurance, Angiotensin converting enzyme inhibitors/angiotensin receptor blockers, statin, beta blocker, smoking, and CKD stage for all models except one model where age was substituted for age >65 to present categorical effect. HR shown were pooled using MIanalyze from five data sets created using multiple imputations.

  • b Includes all deaths related to non-disease causes.

  • c This does not include non-disease cause-related deaths.