Table 6.

Association of Urine PIIINP with the composite of death, 30% eGFR decline, or ESRD among the random subcohort participants in the CHS

Urine PIIINP QuartilesUrine PIIINP Continuous
(Per Doubling)
1234
Urine PIIINP range (μg/L)≤1.391.40–2.582.59–4.22>4.22
No. at risk174183178198
No. with events,a n (%)109117126151
Demographic adjusted,b OR (95% CI)1.00 (reference)1.12 (0.70 to 1.79)2.03 (1.19 to 3.46)2.78 (1.52 to 5.09)1.26 (1.05 to 1.52)
Plus eGFR and urine albumin,c OR (95% CI)1.00 (reference)0.91 (0.56 to 1.49)1.36 (0.77 to 2.40)1.40 (0.71 to 2.73)1.14 (0.98 to 1.33)
Plus CVD risk factors,d OR (95% CI)1.00 (reference)0.99 (0.60 to 1.63)1.62 (0.90 to 2.90)1.65 (0.83 to 3.30)1.18 (1.00 to 1.38)
  • OR, odds ratio.

  • a Within the random subcohort, 440 died, 72 had 30% decline in eGFR, and 14 had incident ESRD events. Because of overlaps, the total event number is 503.

  • b Adjusted for age, sex, race, education, clinic site, and urine creatinine.

  • c Adjusted for demographic variable plus baseline eGFR and urine albumin.

  • d Adjusted for demographic variables eGFR, urine albumin, plus smoking status, pack years, body mass index, diabetes, systolic blood pressure, blood pressure medication use, total cholesterol, lipid medication use, and C-reactive protein.