Table 2.

Acute kidney injury end points in the dexamethasone and placebo groupsa

OutcomeDexamethasone (n=2229)Placebo (n=2236)RR (95% CI)P Value
Primary Outcome
 AKI-RRT10 (0.4)23 (1.0)0.44 (0.19 to 0.96)0.02
Secondary Outcomes
 Doubling of serum creatinine and/or AKI-RRT)72 (3.2)96 (4.3)0.75 (0.55 to 1.03)0.07
 RRT/death29 (1.3)42 (1.9)0.69 (0.42 to 1.13)0.15
 RIFLE “R”: up to 100% increase in SCr142 (6.4)188 (8.4)0.76 (0.61 to 0.94)0.01
 RIFLE “I”: up to 200% increase in SCr66 (3.0)89 (4.0)0.74 (0.54 to 1.03)0.07
 RIFLE “F”: up to 300% increase, or 0.5 mg/dL increase to at least 4.0 mg/dL28 (1.3)42 (1.9)0.67 (0.41 to 1.10)0.09
  • “R”, risk; SCr, serum creatinine; “I”, injury; “F”, failure.

  • a Data are shown as No. (%).