Table 2.

Associations of calcification propensity, serum T50, with all-cause mortality and cardiovascular mortality in stable renal transplant recipients

HighIntermediateLowSerum T50 continuous
HR (95% CI)HR (95% CI)P (trend) ValueHR (95% CI) per SDP Value
All-cause mortality (nevents/ntotal=81/699)
Model 1a1.0 (Ref)1.91 (0.99–3.70)4.09 (2.23 to 7.49)<0.0011.69 (1.37 to 2.09)<0.001
Model 2b1.0 (Ref)1.77 (0.91–3.42)3.77 (2.06 to 6.91)<0.0011.69 (1.36 to 2.09)<0.001
Model 3c1.0 (Ref)1.77 (0.90–3.49)3.54 (1.88 to 6.65)<0.0011.57 (1.26 to 1.97)<0.001
Model 4d1.0 (Ref)2.03 (0.98–4.19)3.50 (1.74 to 7.01)<0.0011.56 (1.23 to 2.00)<0.001
Model 5e1.0 (Ref)1.58 (0.76–3.32)2.86 (1.41 to 5.80)0.0021.43 (1.11 to 1.85)0.006
Cardiovascular mortality (nevents/ntotal=38/699)
Model 1a1.0 (Ref)3.25 (0.88–12.02)7.18 (2.09 to 24.72)0.0011.70 (1.19 to 2.43)0.003
Model 2b1.0 (Ref)3.12 (0.84–11.55)6.82 (1.98 to 23.50)0.0011.71 (1.18 to 2.46)0.004
Model 3c1.0 (Ref)3.02 (0.82–11.19)6.12 (1.75 to 21.44)0.0021.61 (1.10 to 2.36)0.01
Model 4d1.0 (Ref)2.75 (0.74–10.30)6.07 (1.72 to 21.44)0.0021.59 (1.08 to 2.35)0.02
Model 5e1.0 (Ref)2.63 (0.70–9.92)5.58 (1.58 to 19.72)0.0031.55 (1.04 to 2.29)0.03
  • Data are presented as hazard ratio (HR) plus 95% CI according to tertiles of serum T50 and per SD serum T50 decrease. Mean±SD, T50: 286±62 minutes.

  • a Model 1: crude.

  • b Model 2: adjusted for age and gender.

  • c Model 3: adjusted for model 2 plus eGFR (CKD-EPI) and albuminuria.

  • d Model 4: adjusted for model 3 plus current smoking, body mass index, diabetes mellitus, systolic BP and LDL cholesterol.

  • e Model 5: adjusted for model 4 plus high-sensitivity C-reactive protein, calcineurin inhibitor use, dialysis vintage and type of kidney transplant (living versus deceased donor).