Table 2.

Regulated necrosis pathways tested in different models of acute tubular necrosis

ATNRN PathwayIn Vivo/Ex VivoProtectionReference
Ischemic renal injuryNecroptosisIn vivoYes34,78
Ex vivoNo78
FerroptosisIn vivoYes32
MPTIn vivoYes33,34
Delayed graft functionNecroptosisIn vivoYes77
Cisplatin nephrotoxicityNecroptosisIn vivoYes36,81
RhabdomyolysisNecroptosisIn vivoYes82
Contrast media relatedNecroptosisIn vivoYes83
Adriamycin nephrotoxicityNecroptosisIn vivoYes84
Hydroxychloroquine/iron inducedFerroptosisEx vivoYes32
Calcium oxalate crystals relatedFerroptosisIn vivoYes32
NecroptosisIn vivoYesUnpublished data