Table 3.

Sensitivity analyses

AnalysisNo. of PatientsAll-Cause MortalityCardiovascular Mortality
PRA 0%PRA 1%–19%PRA 20%–79%PRA 80%–100%PRA 0%PRA 1%–19%PRA 20%–79%PRA 80%–100%
Primary analysisa161,308Referent1.02 (0.99 to 1.06)1.11 (1.07 to 1.16)1.21 (1.15 to 1.27)Referent1.05 (1.00 to 1.10)1.11 (1.05 to 1.18)1.21 (1.12 to 1.31)
Adjustment for clustering by centera161,308Referent1.02 (0.98 to 1.06)1.11 (1.07 to 1.16)1.21 (1.14 to 1.28)Referent1.05 (0.99 to 1.11)1.11 (1.04 to 1.18)1.21 (1.13 to 1.29)
Model with shared frailty by center161,308Referent1.02 (0.99 to 1.07)1.11 (1.07 to 1.16)1.21 (1.15 to 1.28)Referent1.05 (1.00 to 1.10)1.10 (1.04 to 1.17)1.22 (1.13 to 1.32)
Low risk subcohortb18,645Referent0.97 (0.78 to 1.20)1.25 (1.01 to 1.56)1.53 (1.18 to 2.00)Referent1.29 (0.94 to 1.77)1.64 (1.17 to 2.27)2.03 (1.36 to 3.03)
Activated after 2007c54,584Referent1.05 (0.97 to 1.13)1.06 (0.97 to 1.16)1.33 (1.19 to 1.50)Referent1.16 (1.03 to 1.31)1.13 (0.99 to 1.30)1.26 (1.04 to 1.53)
Unsensitized at activationa117,804Referent1.04 (0.98 to 1.09)1.15 (1.07 to 1.23)1.27 (1.14 to 1.42)Referent1.10 (1.02 to 1.19)1.18 (1.07 to 1.31)1.33 (1.14 to 1.57)
No history of transfusions36,323Referent1.07 (1.01 to 1.14)1.20 (1.11 to 1.30)1.29 (1.15 to 1.44)Referent1.13 (1.03 to 1.23)1.15 (1.02 to 1.30)1.34 (1.14 to 1.58)
Time-fixed PRA measured at activationa161,308Referent1.02 (1.00 to 1.06)1.07 (1.02 to 1.11)1.20 (1.14 to 1.28)Referent1.02 (0.97 to 1.07)1.04 (0.97 to 1.11)1.22 (1.11 to 1.33)
Competing risks modela161,308Referent1.05 (1.01 to 1.08)1.20 (1.15 to 1.25)1.52 (1.44 to 1.62)Referent1.04 (0.98 to 1.09)1.14 (1.07 to 1.22)1.46 (1.34 to 1.60)
  • Data are presented as HRs (95% CIs), unless otherwise indicated.

  • a Model covariates include PRA category, age, sex, race, body mass index, cause of ESRD, dialysis modality, time from dialysis initiation to activation, activation era, multilisting, diabetes, peripheral vascular disease.

  • b Model covariates: PRA category, age, sex, race, body mass index, cause of ESRD, dialysis modality, time from dialysis initiation to activation, activation era, multilisting, and HCV.

  • c Model covariates: PRA category, age, sex, race, body mass index, cause of ESRD, dialysis modality, time from dialysis initiation to activation, multilisting, diabetes, peripheral vascular disease, and HCV.