Table 1.

Baseline characteristics across the QRS and corrected QT intervals

QRS intervalCorrected QT interval (QTc)
Range (ms)<100 ms100–119 ms≥120 ms<450 M/460 W ms≥450 M/460 W ms
Number of participants25227662993292295
Demographics
 Age (years)±SD57±1159±1064±858±1160±10
 Female, n (%)1304 (52)225 (29)94 (31)1500 (46)123 (42)
 Race, n (%)
 White1045 (41)320 (42)125 (42)1402 (43)88 (30)
 Black1037 (41)319 (42)126 (42)1320 (40)162 (55)
 Hispanic332 (13)97 (13)41 (14)437 (13)33 (11)
Prevalent cardiovascular disease
 Coronary artery disease, n (%)434 (17)205 (27)130 (44)666 (20)103 (35)
 Heart failure, n (%)154 (6)85 (11)88 (29)253 (8)74 (25)
 Peripheral vascular disease, n (%)146 (6)57 (7)32 (11)205 (6)30 (10)
 Stroke, n (%)220 (9)93 (12)41 (14)312 (10)42 (14)
Cardiovascular disease risk factors
 Systolic BP (mmHg)±SD128±22131±22131±24128±22138±27
 Diastolic BP (mmHg)±SD72±1372±1469±1371±1373±16
 Hypertension, n (%)2116 (84)697 (91)271 (91)2815 (86)269 (91)
 Diabetes, n (%)1190 (47)359 (47)181 (61)1548 (47)182 (62)
 Body mass index (kg/m2)±SD31.7±8.032.5±7.233.0±7.131.8±7.734.0±7.8
 Smoking status, n (%)
 Current335 (13)96 (13)36 (12)419 (13)48 (16)
 Past996 (40)341 (45)153 (51)1367 (42)123 (42)
 Never1191 (47)329 (43)110 (37)1506 (46)124 (42)
 Total cholesterol (mg/dl)±SD187±46180±44172±42185±46175±43
 HDL (mg/dl)±SD49±1645±1444±1448±1645±14
 LDL (mg/dl)±SD105±36101±3595±34104±3698±35
 Triglycerides (mg/dl)±SD157±115164±132155±115158±117158±139
Echocardiographic variables
 Left ventricular mass index (g/m2.7)±SD102±23116±28125±30105±24129±34
 Left ventricular ejection fraction (%)±SD55±753±948±1355±849±13
 Left ventricular ejection fraction categories
  <35%, n (%)31 (2)33 (5)46 (19)74 (3)36 (16)
  35–50%, n (%)310 (15)134 (21)59 (24)440 (16)63 (28)
  >50%, n (%)1770 (84)467 (74)139 (57)2248 (81)128 (56)
Kidney function
 eGFR (ml/min per 1.73m2)±SD46±1745±1639±1446±1739±16
 eGFR categories (ml/min per 1.73m2)
  <15, n (%)8 (0.3)3 (0.4)0 (0)8 (0.2)3 (1)
  15–30, n (%)473 (19)160 (21)90 (30)623 (19)100 (34)
  30–60, n (%)1544 (61)474 (62)184 (62)2038 (62)164 (56)
  60–90, n (%)453 (18)123 (16)25 (8)575 (18)26 (9)
 ≥90, n (%)44 (2)6 (1)0 (0)48 (2)2 (1)
 Cystatin C (mg/l)±SD.1.48±0.541.53±0.551.72±0.561.49±0.531.75±0.62
 Proteinuria (mg/24 hours),
 Median [IQR]170 [70–920]220 [80–960]210 [80–840]170 [70–890]300 [90–1290]
Serum measures
 Serum calcium (mg/dl)±SD9.2±0.59.2±0.59.1±0.59.2±0.59.0±0.6
 Serum phosphate (mg/dl)±SD3.7±0.73.7±0.73.8±0.73.7±0.73.9±0.7
 Serum potassium (mmol/l)±SD4.4±0.54.3±0.54.3±0.64.4±0.54.2±0.6
 Serum albumin (g/dl)±SD3.9±0.53.9±0.53.9±0.44.0±0.53.8±0.5
 Hemoglobin (g/dl)±SD12.6±1.812.7±1.812.4±1.712.7±1.812.1±1.8
Medications, n (%)
 Aspirin1013 (40)361 (48)175 (59)1403 (43)146 (50)
 Beta blockers1137 (45)422 (56)191 (65)1565 (48)185 (63)
 Calcium channel blockers945 (38)367 (48)124 (42)1301 (40)135 (46)
 Statins1323 (53)449 (59)192 (65)1800 (55)164 (56)