Table 2.

Roxadustat dose levels

Roxadustat Dose LevelsLow Weight (40–60 kg)Medium Weight (>60–90 kg)Heavy Weight (>90–140 kg)
1 (initial dose)60 mg100 mg140 mg
1.0–1.5 mg/kg1.1–1.7 mg/kg1.0–1.6 mg/kg
2100 mg140 mg200 mg
1.7–2.5 mg/kg1.6–2.3 mg/kg1.4–2.2 mg/kg
3140 mg200 mg300 mg
2.3–2.5a mg/kg2.2–2.5a mg/kg2.1–2.5a mg/kg
  • Dose adjustments for Hb response: if Hb was <11.0 g/dl and the rate of rise of Hb was <1.0 g/dl in the previous 4 weeks, the roxadustat dose was escalated up one dose level. The maximum allowed dose was 2.5 mg/kg. If Hb was >13.0 g/dl or rate of rise of Hb was ≥2.0 g/dl in the previous 4 weeks (excessive response), the roxadustat dose was reduced by one dose level, or by approximately 30% if the patient was at dose level 1.

  • a Roxadustat dose subject to a maximum of 2.5 mg/kg thrice weekly.