Table 4.

Change in serum iron variables overall and by treatment group

VariableHD, No Iron HD, Oral Iron (n=12)HD, IV Iron (n=10)PD, Oral Iron (n=10)Total (n=55)
Serum iron
 Patients (n)2312101055
 Baseline (μM)9.7±0.612.8±1.810.3±1.09.5±0.810.4±0.5
ΔEOT(μM)−2.1±0.91.2±2.51.4±1.60.4±1.6−0.3±0.8
P value for EOT0.031NSNSNSNS
Ferritin
 Patients (n)2312101055
 Baseline (ng/ml)156±13163±31182±27137±27159±11
ΔEOT(ng/ml)−120±12−51±25−25±34−65±29−78±12
P value for EOT<0.001NSNS0.054<0.001
Transferrin
 Patients (n)2312101055
 Baseline (μM)26.9±0.926.6±0.926.7±1.326.6±2.426.7±0.6
ΔEOT(μM)9.5±1.25.7±1.75.5±1.45.6±2.97.1±0.8
P value for EOT<0.0010.0080.004NS0.085
TIBC
 Patients (n)2312101055
 Baseline (μM)44.7±1.645.2±1.744.4±2.145.8±4.254.0±1.1
ΔEOT(μM)17.4±2.010.1±3.39.7±2.49.1±4.812.9±1.5
P value for EOT<0.0010.0110.003NS<0.001
sTfR
 Patients (n)2310101053
 Baseline (ng/ml)3.1±0.33.4±0.43.7±0.73.2±0.43.3±0.2
ΔEOT(ng/ml)4.3±0.91.8±1.02.5±0.62.6±0.83.2±0.5
P value for EOT<0.001NS0.0040.011<0.001
TSAT
 Patients (n)2310101053
 Baseline (%)18.8±0.819.0±1.018.1±1.519.3±1.818.8±0.6
ΔEOT(%)−7.4±1.42.6±2.50.7±2.9−1.6±2.6−2.7±1.2
P value for EOT<0.001NSNSNS0.026
Iron-depletea
 Patients (n)2310101053
 Baseline (%)16±69.68±66.78±80.07±70.039±70.9
 EOT (%)23±10010±83.36±60.09±90.048±87.3
P value for EOT0.016NSNSNSNS
CHr
 Patients (n)2110101051
 Baseline (pg)31.0±0.331.6±0.531.5±0.530.5±0.431.1±0.2
Δ4wk(pg) −1.3±0.4−0.5±0.5−0.4±0.5−0.7±0.6−0.8±0.2
P value for 4 wk 0.005NSNSNS0.002
ΔEOT(pg)−2.2±0.7−1.9±0.9−1.0±0.6−0.2±0.6−1.5±0.4
P value for EOT0.003NSNSNS<0.001
  • Unless otherwise noted, data are expressed as mean±SEM for the EE population using the last-observation-carried-forward imputation method. Baseline for iron variables was defined as the mean available values obtained before the first dose. P values are from paired t test: comparison to baseline values, except for iron-deplete, for which P value is from McNemar test. ΔEOT, change from baseline at end of therapy; NS, not significant; EOT, values at end of treatment; TIBC, total iron-binding capacity; sTfR, soluble transferrin receptor; CHr, reticulocyte Hb content; Δ4wk, change from baseline after 4 weeks.

  • a Iron-deplete: TSAT <20% or ferritin <100 ng/ml.