Table 2.

Renal parameters at presentation and histopathologic characteristics

CharacteristicKidney (+) MCVEssential MCVprimary Sjögren SyndromeHematologic MalignancyP Value
Clinical and biologic parametersn=80n=39n=18n=23
Hypertension, n (%)58 (85.3)31 (88.6)11 (78.6)16 (84.2)0.66
Proteinuria, mean±SD3.5±33.7±3.73.4±1.73.1±2.20.80
 ≥ 1 g/d, n (%)67 (84.8)31 (79.5)17 (100)19 (82.6)0.14
 ≥ 3 g/d, n (%)39 (49.4)20 (51.3)10 (58.8)9 (39.1)0.44
Hematuria, n (%)76 (97.4)38 (97.4)15 (93.8)23 (100)0.48
eGFR, mean±SD39.5±20.438.5±22.537.9±17.942.2±18.90.56
 <60 ml/min per 1.73 m2, n (%)65 (82.3)33 (84.6)15 (88.2)17 (73.9)0.44
 <30 ml/min per 1.73 m2, n (%)30 (38)17 (43.6)6 (35.3)7 (30.4)0.29
Dialysis, n (%)4 (5.1)2 (5.1)0 (0)2 (8.7)0.46
Renal histopathologic lesionsn=67n=29n=17n=21
Glomerular lesions
 MPGN, n (%)62 (92.5)27 (93.1)16 (94.1)19 (90.5)0.90
 Mesangial proliferative GN, n (%)5 (7.5)2 (6.9)1 (5.9)2 (9.5)0.90
 Intraluminal thrombi, n (%)32 (47.8)11 (37.9)13 (76.5)8 (38.1)0.02
 Crescentic extracapillary proliferation9 (13.4)6 (20.7)1 (5.9)2 (9.5)0.30
 Lobular pattern10 (14.9)6 (20.7)3 (17.6)1 (4.8)0.80
Vascular lesions
 Acute vasculitis12 (17.9)5 (17.2)4 (23.5)3 (14.3)0.76
 Arteriolosclerosis24 (35.8)11 (37.9)3 (17.6)10 (47.6)0.15
 Arteriosclerosis35 (62.5)15 (65.2)6 (42.9)6 (42.9)0.18
Tubulointerstitial lesions
 Interstitial fibrosis41 (61.2)20 (69.0)11 (64.7)10 (47.6)0.29
 Moderate-to-severe13 (20.3)7 (24.1)4 (23.5)2 (9.5)0.10
 Acute tubular necrosis21 (31.3)11 (37.9)4 (23.5)6 (28.6)0.56
 Interstitial inflammatory infiltration38 (56.7)17 (58.6)9 (52.9)12 (57.1)0.93
 Lymphoid nodules16 (23.9)7 (24.1)5 (29.4)4 (19.0)0.76
  • MCV, mixed cryoglobulinemia vasculitis; MPGN, membranoproliferative GN.