Table 3.

Hazards ratios for death by year of RRT inception, for patients with multiple myeloma (n=12,702)

Year
2003–20042005–20062007–20082009–2010
Hazards Ratio (95% CI)P valueHazards Ratio (95% CI)P valueHazards Ratio (95% CI)P valueHazards Ratio (95% CI)P value
Model 1
All0.99 (0.93 to 1.06)0.90.89 (0.83 to 0.95)0.0010.83 (0.77 to 0.89)<0.0010.72 (0.67 to 0.77)<0.001
Age, years
 <400.66 (0.32 to 1.36)0.30.39 (0.18 to 0.84)0.020.69 (0.34 to 1.39)0.30.79 (0.36 to 1.71)0.5
 40–641.04 (0.92 to 1.18)0.50.94 (0.83 to 1.06)0.30.81 (0.71 to 0.92)0.0010.74 (0.64 to 0.85)<0.001
 ≥651 (0.92 to 1.09)0.90.92 (0.85 to 1)0.040.86 (0.79 to 0.94)<0.0010.73 (0.67 to 0.8)<0.001
Sex
 Men1.03 (0.94 to 1.13)0.50.91 (0.83 to 1)0.040.86 (0.78 to 0.94)0.0010.7 (0.64 to 0.78)<0.001
 Women0.95 (0.86 to 1.05)0.30.87 (0.79 to 0.96)0.010.79 (0.71 to 0.87)<0.0010.74 (0.66 to 0.83)<0.001
Race/ethnicity
 White0.98 (0.91 to 1.06)0.70.89 (0.82 to 0.96)0.0030.81 (0.75 to 0.88)<0.0010.71 (0.65 to 0.77)<0.001
 Black1.08 (0.93 to 1.26)0.30.92 (0.79 to 1.07)0.30.94 (0.81 to 1.1)0.50.77 (0.66 to 0.91)0.003
 Hispanic1.02 (0.76 to 1.37)0.90.82 (0.62 to 1.1)0.20.76 (0.57 to 1.02)0.070.81 (0.59 to 1.11)0.2
 Other0.74 (0.48 to 1.14)0.20.89 (0.56 to 1.4)0.60.76 (0.5 to 1.16)0.20.49 (0.29 to 0.82)0.01
Model 2
All1.01 (0.95 to 1.08)0.70.92 (0.86 to 0.98)0.010.85 (0.79 to 0.91)<0.0010.73 (0.68 to 0.79)<0.001
Age, years
 <400.63 (0.29 to 1.36)0.20.33 (0.14 to 0.75)0.010.73 (0.35 to 1.51)0.40.78 (0.36 to 1.71)0.5
 40–641.05 (0.93 to 1.18)0.50.93 (0.83 to 1.05)0.20.81 (0.71 to 0.92)0.0010.74 (0.64 to 0.84)<0.001
 ≥651 (0.92 to 1.09)10.92 (0.85 to 0.99)0.030.86 (0.79 to 0.94)<0.0010.73 (0.67 to 0.8)<0.001
Sex
 Men1.04 (0.95 to 1.14)0.40.93 (0.85 to 1.01)0.090.86 (0.79 to 0.94)0.0010.7 (0.63 to 0.78)<0.001
 Women0.98 (0.89 to 1.08)0.70.9 (0.82 to 1)0.050.82 (0.74 to 0.92)<0.0010.78 (0.7 to 0.88)<0.001
Race/ethnicity
 White0.99 (0.92 to 1.08)0.90.91 (0.84 to 0.98)0.020.82 (0.76 to 0.89)<0.0010.71 (0.65 to 0.78)<0.001
 Black1.11 (0.95 to 1.29)0.20.99 (0.85 to 1.15)0.90.96 (0.82 to 1.12)0.60.8 (0.68 to 0.95)0.01
 Hispanic1.05 (0.78 to 1.41)0.80.8 (0.6 to 1.06)0.10.78 (0.58 to 1.05)0.10.81 (0.59 to 1.11)0.2
 Other0.81 (0.53 to 1.24)0.30.84 (0.53 to 1.33)0.50.85 (0.56 to 1.3)0.50.54 (0.32 to 0.92)0.02
Model 3
All1.02 (0.95 to 1.09)0.50.93 (0.87 to 0.99)0.020.86 (0.8 to 0.92)<0.0010.74 (0.68 to 0.79)<0.001
Age, years
 <400.53 (0.23 to 1.24)0.10.31 (0.13 to 0.73)0.010.54 (0.25 to 1.17)0.120.53 (0.22 to 1.31)0.2
 40–641.07 (0.94 to 1.2)0.30.94 (0.83 to 1.06)0.30.82 (0.72 to 0.93)0.0030.73 (0.63 to 0.83)<0.001
 ≥651.01 (0.93 to 1.09)0.80.93 (0.86 to 1.01)0.070.88 (0.81 to 0.95)0.0020.74 (0.68 to 0.81)<0.001
Sex
 Men1.05 (0.96 to 1.15)0.30.94 (0.86 to 1.03)0.20.88 (0.8 to 0.97)0.010.71 (0.64 to 0.78)<0.001
 Women0.99 (0.89 to 1.09)0.80.91 (0.83 to 1.01)0.070.83 (0.75 to 0.92)0.0010.79 (0.7 to 0.88)<0.001
Race/ethnicity
 White1 (0.93 to 1.08)10.92 (0.85 to 0.99)0.030.84 (0.77 to 0.91)<0.0010.72 (0.66 to 0.79)<0.001
 Black1.11 (0.96 to 1.29)0.21.01 (0.87 to 1.18)0.91 (0.86 to 1.17)10.81 (0.68 to 0.95)0.01
 Hispanic1.02 (0.76 to 1.39)0.90.77 (0.58 to 1.04)0.090.73 (0.54 to 0.99)0.040.78 (0.56 to 1.07)0.1
 Other0.8 (0.51 to 1.25)0.30.85 (0.53 to 1.36)0.50.8 (0.51 to 1.25)0.30.55 (0.32 to 0.93)0.03
  • RRT inception in 2001–2002 is the reference category throughout. Model 1, unadjusted; model 2, adjusted for age, sex, race, and ethnicity; model 3, adjusted for age, sex, race, ethnicity, ischemic heart disease, diabetes, mode of RRT, eGFR, body mass index, serum albumin, and hemoglobin.