Table 3.

Clinical and demographic characteristics of LCPT

CharacteristicAll Patients (n=46)Crystalline (n=40)Noncrystalline (n=6)
Age, yra62.5 (60)61.4 (59)74.5 (72)
(Range)(39–87)(39–87)(61–87)
Male (%)636833
White (%)8583100
Serum monoclonal spike32/45 (71%)27/39 (69%)5/6 (83%)
Urine monoclonal spike31/33 (94%)29/30 (97%)2/3 (66%)
Positive FLC10/11 (91%)8/9 (89%)2/2 (100%)
Hematologic diagnoses
 MM15105
 Smoldering myeloma761
 MGRS21210
 Other diagnosesb330
FS17/43 (40%)17/38 (43.4%)0/5 (0%)
SCr, mg/dla2.38 (2.0)2.4 (2.1)2.4 (1.0)
eGFR by CKD-EPI, ml/min per 1.73 m2a38.3 (36.4)35.3 (34.6)53.8 (60.5)
eGFR<60, ml/min per 1.73 m2 38/46 (83%)35/40 (88%)3/6 (50%)
AKI10/46 (22%)8/40 (20%)2/6 (33%)
Proteinuria, g/24 ha3.07 (2.51)2.97 (2.45)4.4 (4.2)
 <1642
 1–323230
 >317134
Serum albumin, g/dlc4.0±0.14.0±0.14.1±0.2
  • CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration 2009 formula28; FLC, free light chain assay; SCr, serum creatinine.

  • a Values are mean (median).

  • b Other diagnoses: non-Hodgkin lymphoma (n=2) and chronic lymphocytic leukemia (n=1).

  • c Mean±SEM.