Table 3.

Addition of CFR to a multivariable Cox regression model for cardiovascular mortality (secondary end point)

Fit StatisticModel 1Model 2 (Model 1 + ln CFR)
Estimate/HR (95% CI)P ValueEstimate/HR (95% CI)P Value
Global chi squared31.5Reference40.50.003
Age, yr1.01 (0.97 to 1.06)0.531.01 (0.96 to 1.05)0.77
Overt CVD4.47 (1.26 to 15.94)0.024.75 (1.35 to 16.76)0.02
Ischemia + scar, % myocardium1.06 (1.03 to 1.09)<0.0011.04 (1.01 to 1.07)0.002
ln CFR (per 0.5-unit increase)0.01 (<0.01 to 0.15)0.002
  • Model 2 adds ln CFR to model 1. Overt cardiovascular disease (CVD) was defined as one or more of the following: prior myocardial infarction, stroke, percutaneous coronary intervention, coronary artery bypass, or peripheral arterial revascularization. HR, hazard ratio.