Table 2.

Addition of CFR to a multivariable Cox regression model for all-cause mortality (primary end point)

Fit StatisticModel 1Model 2 (Model 1 + ln CFR)
Estimate/HR (95% CI)P ValueEstimate/HR (95% CI)P Value
Global chi squared42.2Reference54.30.001
Age, yr1.04 (1.01 to 1.08)0.021.04 (1.01 to 1.08)0.04
Overt CVD2.39 (1.04 to 5.47)0.042.50 (1.10 to 5.66)0.03
Ischemia + scar, % myocardium1.05 (1.03 to 1.08)<0.0011.04 (1.02 to 1.06)0.001
ln CFR (per 0.5-unit increase)0.01 (<0.01 to 0.14)<0.001
  • Model 2 adds ln CFR to model 1. Overt cardiovascular disease (CVD) was defined as one or more of the following: prior myocardial infarction, stroke, percutaneous coronary intervention, coronary artery bypass, or peripheral arterial revascularization. HR, hazard ratio.