Table 1.

Comparisons of demographic and biologic parameters between HU onset (baseline) and after 6 months of treatment (follow-up; n=58)

Parameter (n)BaselineFollow-UpP Value
eGFR (ml/min per 1.73 m2)124.5 [112–132]120.5 [112–129]0.15
Albuminuria (mg/L)22 [10–56]14 [6–53]0.02
ACR (mg/mmol)3 [1.3–10.5]1.7 [1–7]<0.01
ACR subgroups
 Normal, <3 mg/mmol (29)1.3 [0.9–2.4]1.3 [0.4–1.9]0.76
 Microalbuminuria (23)8.1 [4.9–17.8]2.3 [1.1–7.1]0.03
 Macroalbuminuria (6)72 [37–119]36 [22–75]0.15
Body mass index21.2 [19.2–22.9]21.7 [19.6–23.2]0.002
Body surface area (m2)1.75 [1.65–1.83]1.75 [1.65–1.86]0.002
Systolic BP (mmHg)114 [103–122]117 [109–127]0.78
Diastolic BP (mmHg)70 [64–75]70 [60–71]0.48
VOCs during the last 6 mo8116<0.001
White blood cells (×109/L)9.1 [8–11.7]6.8 [5.2–8.5]<0.001
Platelets (×109/L)366 [271–424]272 [210–366]<0.01
Hb (g/dl)8.9 [8–10]9.9 [8.9–10.7]<0.001
Reticulocytes (×109/L)262[178–294]121 [90–181]<0.001
Mean corpuscular volume (fl)89[83–94]106 [96–115]<0.001
MCHC (g/dl)33.5[33–35]33 [33–34]0.24
MCH (pg)30 [28–32]35 [33–39]<0.001
HbF (%)5.7 [2.5–8.4]14.4 [8.8–23.3]<0.001
%DRBCs>1.1110.5 [5–20.5]6 [2–10.5]<0.001
Serum creatinine (μmol/L)52 [44–64]54 [45–65]0.31
Urine creatinine (mmol/L)7.2 [4.8–8.6]6.3 [4.6–9.4]0.86
BUN (mmol/L)3.1 [2.3–3.8]3 [2.4–3.9]0.64
LDH (IU/ml)408 [316–582]344 [261–500]0.003
AST (IU/L)51 [27–58]35 [27–53]0.04
Alanine aminotransferase (IU/L)25 [15–36]25 [16–37]0.79
Total bilirubin (µmol/L)37 [26–60]28 [16–44]<0.001
  • Values are expressed as medians [interquartile ranges], except for VOCs during the last 6 months, which are expressed as absolute numbers.