Table 2.

Correlation between clinical or biologic parameter variation and ACR change (n=39)

ParameterBivariate Analysis
rP Value
Body mass index0.110.50
Body surface area0.080.60
Systolic BP0.510.02
Diastolic BP0.170.40
VOC variationa0.170.30
White blood cells0.290.08
Mean corpuscular volume−0.040.70
MCHC0.330.05
MCH0.040.80
Hb0.130.40
HbF (%)−0.110.50
%DRBCs0.390.02
Reticulocytes0.130.40
Platelets0.010.90
eGFR0.260.11
BUN0.170.30
Total bilirubin0.310.05
Alanine aminotransferase0.240.20
AST0.380.02
LDH0.43<0.01
  • a VOC variation: comparison of the numbers of VOCs occurring during the 6 months before starting HU and the 6 months thereafter.