Table 1.

Body weight, urine, and blood parameters in WT and κLC transgenic mice

ParameterWTκCHκDE
Body weight (g)27.8±0.526.5±0.527.9±1.8
U volume (µl/24 h)1361±922024±153a1384±176
U albumin (µM/mg creatinine per deciliter)1073±143776±266957±395
U CC16 (µg/g creatinine)11±1.5148±13.3b20±7.8
U calcium (mg/g creatinine)64±453±497±15
U phosphate (mg/g creatinine)87±7133±7.5b84±16
U glucose (mg/g)1.4±0.22.2±0.3c1.4±0.1
U creatinine (mg/dl)62±457±661±9
BUN (mg/dl)21±1.222±1.624±1.7
P creatinine (mg/dl)0.094±0.010.096±0.010.09±0.01
  • Seven mice per group. U, urine; CC16, Clara cell protein; P, plasma.

  • a P<0.01 versus the WT and κDE.

  • b P<0.001 versus the WT and κDE.

  • c Р<0.05 versus the WT and κDE.