Table 2.

Evolution of serum calcium, phosphate, iPTH, biomarkers of bone turnover, renal function, and vascular calcification

VariableCinacalcetSubtotal Parathyroidectomy
BaselineMonth 3Month 6Month 12BaselineMonth 3Month 6Month 12
Albumin, g/L43.9±2.844.1±1.943.9±2.543.7±3.144.5±2.444.4±2.844.1±3.343.4±3.0
Calcium, mmol/L2.72±0.12.42±0.2a2.42±0.2a2.37±0.2a2.78±0.22.28±0.2b2.26±0.2b2.22±0.2b
iPTH, pmol/L25±1218±7a20±9a22±1137±189±10b7±6b6±5b
Phosphorus, mmol/L0.92±0.21.1±0.1a1.0±0.2a1.1±0.1a0.93±0.21.3±0.2b1.3±0.2b1.3±0.3b
25(OH)D3 for calcidiol, nmol/L51±2457±2159±2153±1541±1490±32b79±31b70±30b
Bone resorption biomarker
 C-terminal telopeptide, μg/L0.48±0.220.72±0.44a0.72±0.35a0.71±0.45a0.48±0.270.26±0.24b0.13±0.14b0.33±0.35b
Bone formation biomarkers
 Alkaline phosphatase, μKat/L2.2±1.72.2±1.12.2±1.21.5±0.5a1.9±0.92.2±1.61.8±1.21.7±1.1b
 Osteocalcin, μg/L32±1641±2337±1740±2728±1925±1825±822±13b
Renal function
 eGFR, ml/min57±1154±1653±648±14a57±1652±1453±1753±14
 Proteinuria, mg/d195±150144±110171±135200±169243±150264±273234±229251±362
Vascular calcification
 Abdominal aorta calcification score4.9±3.45.1±3.85.2±3.94.9±3.85.0±3.85.0±3.8
 Vascular calcification score17.0±13.518.6±13.818.8±14.217.7±12.717.3±13.717.6±13.7
  • 25(OH)D3, 25-hydroxy vitamin D (calcidiol); μKat, katal; —, not done as per protocol.

  • a P<0.05 versus baseline in the cinacalcet group.

  • b P<0.05 versus baseline in the subtotal parathyroidectomy group.