Table 4.

Analysis of the extreme deciles (10% and 90%) for the genic and PKD1 allelic variables

Phenotype and GeneMost Severe 10%Least Severe 10%P Value
Genic
 eGFR (%)<0.0001
  PKD1106 (95.5)61 (55.0)
  PKD22 (1.8)37 (33.3)
  NMD3 (2.7)13 (11.7)
 htTKV (%)<0.0001
  PKD158 (87.8)24 (36.4)
  PKD24 (6.1)23 (34.8)
  NMD4 (6.1)19 (28.8)
PKD1 allelic effect
 eGFR (%)<0.0001
  Truncating67 (77.0)41 (47.1)
  Nontruncating20 (23.0)46 (52.9)
 htTKV (%)0.05
  Truncating36 (72.0)27 (52.9)
  Nontruncating14 (28.0)24 (47.1)
PKD1 mutation strength
 eGFR (%)0.0002
  Truncating: MSG167 (77.0)41 (47.1)
  Nontruncating: MSG211 (12.7)21 (24.2)
  Nontruncating: MSG39 (10.3)25 (28.7)
 htTKV (%)0.005
  Truncating: MSG136 (72.0)27 (52.9)
  Nontruncating: MSG211 (22.0)8 (15.7)
  Nontruncating: MSG33 (6.0)16 (31.4)