Table 2.

Risk factors for adverse clinical outcomes

Clinical OutcomeYears Follow-up, Mean (SD)Risk FactorHR (95% CI)P Value
Proteinuria(n=215)16.6 (11.5)BMIa1.10 (1.06 to 1.13)<0.001
Male gender1.56 (1.18 to 2.05)<0.001
Related to recipient0.58 (0.36 to 0.96)0.03
eGFR<60 ml/min per 1.73 m2(n=1410)9.5 (11.3)Older age at donationa1.05 (1.04 to 1.06)<0.001
BMIa1.03 (1.01 to 1.04)<0.001
Systolic BPa1.01 (1.00 to 1.01)<0.001
Diastolic BPa0.99 (0.98 to 1.00)<0.001
Type 2 diabetes1.52 (1.13 to 2.03)<0.001
Related to recipient0.56 (0.48 to 0.65)<0.001
eGFR (CKD-EPI) a0.98 (0.98 to 0.98)<0.001
eGFR<45 ml/min per 1.73 m2(n=428)11.0 (12.1)Older age at donationa1.07 (1.05 to 1.08)<0.001
BMIa1.03 (1.01 to 1.06)<0.001
Systolic BPa1.01 (1.01 to 1.02)<0.001
Related to recipient0.53 (0.39 to 0.71)<0.001
eGFR (CKD-EPI)a0.97 (0.96 to 0.97)<0.001
eGFR<30 ml/min per 1.73 m2(n=101)11.4 (12.4)Older age at donationa1.07 (1.05 to 1.10)<0.001
BMIa1.09 (1.04 to 1.14)<0.001
eGFR<30 ml/min per 1.73 m2or ESRD(n=112)15.5 (12)Older age at donationa1.07 (1.05 to 1.09)<0.001
BMIa1.08 (1.04 to 1.13)<0.001
Systolic BPa1.02 (1.00 to 1.04)0.01
ESRD (n=28)16.5 (11.9)Systolic BPa1.04 (1.01 to 1.07)0.02
  • CKD-EPI, CKD Epidemiology Collaboration equation.

  • a Per increment of 1 unit—i.e., per year increment (for older age at donation), per kg/m2 increment for BMI, per mmHg increment for BP, per ml/min per 1.73 m2 increment for eGFR.