Table 2.

Significance of sex and genotypes to the eGFR and htTKV phenotypes and ICC analysis: Kidney disease

Variable and PopulationeGFRa Difference (P Value)htTKV Difference, % (P Value)FigureICC eGFR (P Value)ICC htTKV (P Value)
Sex: Womenb
 Total study+4.34 (0.0002)c−22.1 (<0.0001)cFigure 1, A and B0.12 (0.06)0.46 (<0.001)c
 PKD1+3.48 (0.009)c−19.7 (<0.0001)cFigure 1, C and D0.13 (0.07)0.40 (<0.001)c
 PKD2+8.47 (0.002)c−19.7 (0.07)Figure 1E, Supplemental Figure 10.09 (0.32)0.63 (0.01)c
Gene
 Total studyFigure 2, A and B0.12 (0.06)0.46 (<0.001)c
 PKD2d+13.49 (<0.0001)c−34.3 (<0.0001)c
 NMDd+9.42 (<0.0001)c−30.9 (<0.0001)c
Mutation position: 3′ halfe
 PKD1−2.18 (0.11)+7.8 (0.06)Supplemental Figure 2, A and B0.13 (0.07)0.39 (<0.001)c
 PKD2−2.05 (0.45)−15.2 (0.12)Supplemental Figure 2, C and D0.07 (0.34)0.62 (0.02)c
Mutation type: PKD1Figure 3, A and B0.12 (0.09)0.46 (<0.001)c
 Splicef−1.06 (0.65)+1.0 (0.94)
 Nonsensef+0.45 (0.46)−3.9 (0.46)
 Missensef+6.16 (0.0004)c−10.4 (0.06)
 In frame D/If+5.63 (0.05)+6.2 (0.46)
Mutation effect: Nontruncatingg
 PKD1+5.09 (0.0003)c−5.8 (0.16)Figure 3, C and D0.13 (0.07)0.40 (<0.001)c
 PKD2+3.34 (0.34)−10.4 (0.35)Supplemental Figure 30.09 (0.31)0.63 (0.01)c
Mutation group: PKD1Figure 4, A and B0.14 (0.06)0.39 (<0.001)c
 MSG2h+2.90 (0.09)+3.2 (0.71)
 MSG3h+7.80 (<0.0001)c−17.3 (0.003)c
  • D/I, deletion or insertion.

  • a In milliliters per minute per 1.73 m2 calculated using the CKD-EPI equation.

  • b Versus men.

  • c Significant.

  • d Versus PKD1.

  • e Versus 5′ half.

  • f Versus frameshifting.

  • g Versus truncating.

  • h Versus MSG1.