Table 1.

Allelic associations for rs6677604 and different CNVs within CFHR3 and CFHR1

VariantsBeijing Cohort, n=2067, 1185 Patients/882 Controls Shanghai Cohort, n=1472, 722 Patients/750 ControlsCohorts Combined, n=3539, 1907 Patients/1632 Controls
MAF Patients/ControlsOR (95% CI)P ValueMAF Patients/ControlsOR (95% CI)P ValueMAF Patients/ControlsOR (95% CI)P Value
rs6677604 (A)0.040/0.0720.55 (0.42 to 0.72)1.4 × 10−50.051/0.0700.71 (0.52 to 0.96)0.020.044/0.0710.61 (0.50 to 0.75)1.6 × 10−6
CFHR3-CFHR1
 Del-Del0.037/0.0710.51 (0.38 to 0.67)2.3 × 10−60.046/0.0690.65 (0.48 to 0.90)8.3 x 10−30.040/0.0700.56 (0.46 to 0.70)8.5 × 10−8
 Wt-Del0.0076/0.00850.89 (0.45 to 1.78)0.74 (NS)0.012/0.0111.10 (0.56 to 2.16)0.78 (NS)0.0094/0.00980.96 (0.59 to 1.56)0.87 (NS)
 Del-Wt0.0025/0.00340.74 (0.24 to 2.31)0.61 (NS)0.006/0.0041.57 (0.55 to 4.42)0.40 (NS)0.0039/0.00371.07 (0.50 to 2.29)0.86 (NS)
 Wt-Dup0.0042/0.00341.24 (0.45 to 3.43)0.68 (NS)0.003/0.0050.59 (0.17 to 2.03)0.40 (NS)0.0037/0.00400.92 (0.43 to 1.97)0.83 (NS)
  • MAF, minor allele frequency; Del, deletion; Wt, wild type; Dup, duplication.