Association between PPI and risk of eGFR<60 ml/min per 1.73 m2, and risk of CKD
| Outcome | H2 Blockers (n=20,270) | PPI (n=173,321) | |
|---|---|---|---|
| Incident eGFR<60 ml/min per 1.73 m2 | Number of events (%) | 4,429 (21.85) | 48,171 (27.79) |
| Incident rate (95% CI) | 5408.24 (5248.96 to 5567.52) | 7241.27 (7176.61 to 7305.94) | |
| HR (95% CI) | 1.0 | 1.22 (1.18 to 1.26) | |
| Incident chronic kidney disease | Number of events (%) | 2,234 (11.02) | 26,193 (15.11) |
| Incident rate (95% CI) | 2569.86 (2463.30 to 2676.43) | 3683.12 (3638.52 to 3727.72) | |
| HR (95% CI) | 1.0 | 1.28 (1.23 to 1.34) |
Incident rate as incident per 100,000 person-years.
HRs were obtained from Cox models adjusted for baseline eGFR, age, race, sex, diabetes mellitus, hypertension, cardiovascular disease, peripheral artery disease, cerebrovascular disease, chronic lung disease, hepatitis C, HIV, dementia, gastroesophageal reflux disease, upper gastrointestinal tract bleeding, ulcer disease, H. pylori infection, Barrett esophagus, achalasia, stricture, and esophageal adenocarcinoma.