Table 4.

Association between circulating APOL1 levels and CKD in nondiabetic DHS black participants

OutcomeAPOL1 proteinN subjectsModel 1Model 2
OR (95% CI)P ValueOR (95% CI)P Value
CKDTotal APOL114790.95 (0.78 to 1.15)0.580.99 (0.82 to 1.21)0.96
WT APOL112391.02 (0.81 to 1.28)0.861.19 (0.87 to 1.62)0.28
G1 APOL15881.22 (0.96 to 1.55)0.111.14 (0.85 to 1.52)0.38
G2 APOL14021.25 (0.92 to 1.70)0.161.24 (0.88 to 1.75)0.23
G1+G2 APOL18921.44 (1.19 to 1.75)<0.0011.17 (0.92 to 1.50)0.2
MicroalbuminuriaTotal APOL114740.91 (0.74 to 1.12)0.390.95 (0.77 to 1.18)0.63
WT APOL112371.02 (0.79 to 1.30)0.891.19 (0.85 to 1.66)0.32
G1 APOL15841.17 (0.90 to 1.52)0.241.07 (0.79 to 1.47)0.65
G2 APOL14001.08 (0.76 to 1.55)0.661.06 (0.73 to 1.55)0.75
G1+G2 APOL18871.32 (1.07 to 1.63)<0.0011.07 (0.82 to 1.39)0.64
GFR<60 ml/min/1.73 m2Total APOL115340.82 (0.58 to 1.17)0.270.88 (0.62 to 1.25)0.47
WT APOL112870.94 (0.61 to 1.44)0.780.83 (0.47 to 1.48)0.53
G1 APOL16031.10 (0.71 to 1.72)0.660.98 (0.58 to 1.63)0.92
G2 APOL14151.61 (0.96 to 2.68)0.071.80 (0.96 to 3.38)0.07
G1+G2 APOL19201.64 (1.20 to 2.24)0.0021.20 (0.79 to 1.81)0.39
  • The analysis includes nondiabetic DHS black participants with available data on microalbuminuria, GFR and total CKD. The analysis of allele-specific protein levels is restricted to individuals who carry at least one copy of the corresponding allele. For example, the analysis of WT APOL1 levels is confined to individuals with 0 or 1 copies of the G1 and G2 alleles. The analysis of total levels of the variant protein (G1+G2 APOL1) is restricted to individuals with at least one copy of the variant alleles (G1 or G2). Model 1 includes age, gender, and systolic BP as covariates. Model 2 is additionally adjusted for the number of copies of the risk alleles. OR are calculated per 1 SD increase in circulating APOL1 levels. N subjects, number of individuals included in each analysis. 95% CI, 95% confidence interval.