Table 4.

Cox proportional hazard analysis for PAG and free p-cresyl sulfate

ModelPAG (Ln)Free p-Cresyl Sulfate (Ln)
HR (95% CI)P ValueHR (95% CI)P Value
Mortality
 Unadjusted2.17 (1.57 to 2.99)<0.0012.23 (1.57 to 3.15)<0.001
 Full model1.77 (1.22 to 2.57)0.0031.30 (0.81 to 2.07)0.28
Cardiovascular disease
 Unadjusted2.21 (1.70 to 2.87)<0.0012.25 (1.69 to 2.98)<0.001
 Full model1.79 (1.32 to 2.41)<0.0011.58 (1.15 to 2.17)0.005
  • Full model with adjustment for age, sex, diabetes mellitus, prior cardiovascular disease, and eGFR (Ln). HR is presented per 1-SD increase (95% CI). Ln, natural logarithmic transformation.