Table 4.

Adjusted association between selected metabolites and RR of impaired executive function in replication cohort (n=180)

Adjusted RR (95% CI)
MetaboliteModel OneModel Two
4-hydroxyphenylacetate per SD Increase in Log1.12 (1.02 to 1.22)1.12 (1.02 to 1.23)
Phenylacetylglutamine per SD Increase in Log1.10 (0.98 to 1.25)1.11 (0.98 to 1.26)
Hippurate per SD Increase in Log0.96 (0.83 to 1.06)0.96 (0.86 to 1.08)
Prolyl-hydroxyproline per SD Increase in Log1.11 (0.99 to 1.23)1.11 (1.00 to 1.24)
  • Model 1 is adjusted for age, education, and language. Model 2 is adjusted for age, education, language, stroke, vintage, and day of blood sampling.