Table 2.

Renin+CoRL and RFP+CoRL in JGC

Reservoir of CoRL: Data from JGCRenin+CoRLRFP+CoRL
Total No. of renin+CoRL in JGC per Section (Cortex) Corrected for Section Size# (Represents N in Formula)All Kidney Cells That Are Renin+CoRL in JGC, %Total No. # of RFP+CoRL in JGC Corrected for Section Size (Represents N×P1)All kidney Cells That Are RFP+CoRL in JGC, %
Baseline (no FSGS)
 H2O alone438.8±720.78±0.15442.7±47.50.79±0.13
 Enalapril alone523.05±71.761.09±0.09542±82.621.12±0.01a (P=0.02 versus H2O)
(P=0.22 versus H2O)(P=0.02 versus H2O)(P<0.2 versus H2O)
 Losartan alone1439.9±18.933.09±0.491479±53.433.14±0.57b (P<0.001 versus H2O)
(P<0.001 versus H2O)(P<0.001 versus H2O)(P<0.001 versus H2O)
(P<0.001 versus enalapril)(P<0.001 versus enalapril)
FSGS day 28
 FSGS+H2O399.01±84.960.73±0.12401.5±32.50.76±0.13
(P=0.5 versus baseline)(P=0.6 versus baseline)(P=0.67 versus baseline)(P=0.78 versus baseline)
FSGS+hydralazine422.69±74.970.80±0.23420.31±50.160.80±0.24
(P=0.52 versus FSGS H2O)(P=0.53 versus FSGS H2O)(P=0.9 versus FSGS H2O)(P=0.73 versus FSGS H2O)
 FSGS+enalapril1245.03±237.772.17±0.361282.93±300.662.22±0.44c
(P<0.001 versus FSGS hydralazine)(P<0.001 versus FSGS hydralazine)(P<0.001 versus FSGS hydralazine)(P<0.001 versus FSGS Hydralazine)
 FSGS+losartan1304.07±296.522.48±0.571317.36±294.22.51±0.57d (P<0.001 versus FSGS hydralazine)
(P<0.001 versus FSGS hydralazine)(P<0.001 versus FSGS hydralazine)(P<0.001 versus FSGS hydralazine)
  • a At baseline, enalapril increased the number of RFP+CoRL by 1.23-fold over baseline.

  • b At baseline, losartan increased the number of RFP+CoRL by three-fold over baseline.

  • c In FSGS, enalapril increased the number of RFP+CoRL by 2.92-fold over water or hydralazine treatment.

  • d In FSGS,-losartan increased the number of RFP+CoRL by 3.3-fold over water or hydralazine treatment.