Table 1.

Physiologic parameters of Ndcbe/Ncc dKO, Ncc knockout, and wild-type mice fed an NaCl-depleted diet for 6 days

ParametersNdcbe+/+;Ncc+/+Ndcbe−/−;Ncc−/−Ndcbe+/+;Ncc−/−
Blood
 [K+], mmol/L4.14±0.073.49±0.08a3.61±0.09a
 Hematocrit, %42.4±0.544.5±0.4b42.9±0.6
 Creatinine, μM11.5±0.910.6±1.29.7±0.8
Urine
 Urine output, ml/24 h1.16±0.101.56±0.231.56±0.18
  • Values are the means±SEMs. For K+, n=24, n=11, and n=19 for wild-type (Ndcbe+/+;Ncc+/+), Ndcbe−/−;Ncc−/−, and Ndcbe+/+;Ncc−/− mice, respectively. For hematocrit, n=23, n=11, and n=18 for wild-type (Ndcbe+/+;Ncc+/+), Ndcbe−/−;Ncc−/−, and Ndcbe+/+;Ncc−/− mice, respectively. For creatinine and urine output, n=18, n=11, and n=14 for wild-type (Ndcbe+/+;Ncc+/+), Ndcbe−/−;Ncc−/−, and Ndcbe+/+;Ncc−/− mice, respectively. Statistical significance between groups was assessed by ANOVA following Tukey multiple comparison tests when appropriated. [K+], potassium concentration.

  • a P<0.001 versus wild-type mice.

  • b P<0.05 versus wild-type mice.