Table 2.

Renal scores of nondiabetic and diabetic mice at 16 weeks of age

Histological LesionsNondiabetes (n=5)Diabetes
Veh (n=10)S1 (n=8)
Glomerular lesions
 Hypercellularity0.20±0.19a2.00±0.230.21±0.15a
 Mesangial matrix expansion0.20±0.20a2.30±0.210.38±0.18a
 Capillary dilation0.00±0.00a1.70±0.300.63±0.18c
Tubular lesions
 Degeneration0.40±0.24a2.00±0.260.50±0.19a
 Atrophy0.20±0.20a1.90±0.280.63±0.26b
Interstitial lesions
 Fibrosis0.00±0.00b1.20±0.330.25±0.16c
 Inflammation0.10±0.14a1.80±0.230.38±0.20a
  • PAS-stained renal samples were semiquantitatively graded (0–3 scale) in a blinded manner according to the extent of glomerular, tubular, and interstitial damage. Results from the different groups of mice are reported as means±SEM and analyzed by two-way ANOVA followed by Bonferroni post hoc test. Veh, vehicle.

  • a P<0.001.

  • b P<0.01.

  • c P<0.05 versus Veh.