Table 1.

Demographic and clinical characteristics of the cohort of KTRs who had a biopsy for cause

CharacteristicEntire Cohort, n=242
Age, yr46.6±16
Men, n (%)148 (61)
Cause of ESRD, n (%)
 GN53 (22)
 Diabetes22 (9)
 Cystic/hereditary42 (17)
 Secondary GN9 (4)
 Hypertension22 (9)
 Interstitial nephritis41 (17)
 Miscellaneous8 (4)
 Uncertain45 (18)
Donor age, yr54.5 (17)
Living donor, n (%)57 (23)
Expanded criteria donor, n (%)106 (44)
Retransplantation, n (%)44 (19)
Preformed anti–HLA DSA, n (%)112 (45)
Cold ischemia time, h17±1
Delayed graft function, n (%)64 (27)
Basiliximab, n (%)116 (48)
ATG, n (%)104 (42)
Tacrolimus, n (%)172 (71)
Cyclosporin, n (%)51 (21)
IMPDHi, n (%)214 (95)
MTORi, n (%)16 (5)
Steroids, n (%)232 (96)
uANG/creatinine, ng/mmol454±695
Time to biopsy,a mo40±58
  • Values are means±SD unless otherwise noted. DSA, donor-specific antibody; ATG, antithymocyte globulins; IMPDHi, inhibitor of inositol monophosphate dehydrogenase; MTORi, inhibitor of mechanistic target of rapamycin.

  • a For KTRs with multiple biopsies, the first biopsy after transplantation is taken into account to calculate the interval of time between transplantation and biopsy.