Table 5.

Association of donor YKL-40 with 6-month eGFR, stratified by DGF status

Tertile of YKL-40 (Range [ng/ml])NUnadjustedAdjusted for Donor VariablesaAdjusted for Donor, Transport, and Recipient VariablesbAdjusted for Donor, Transport, Recipient Variables, and Donor NGALc
Recipients without DGF
 T1 (<0.61) (referent)n1=62062.09 (59.97 to 64.21)54.81 (51.82 to 57.80)56.26 (52.87 to 59.65)55.69 (52.23 to 59.15)
 T2 (0.61–3.31)n2=588−2.29 (−5.19 to 0.61)−0.15 (−2.66 to 2.36)0.50 (−2.01 to 3.01)1.17 (−1.43 to 3.76)
 T3 (3.33–432.78)n3=471−5.59 (−8.64 to −2.55)−2.19 (−5.00 to 0.62)−1.58 (−4.38 to 1.22)0.13 (−3.29 to 3.54)
Recipients with DGF
 T1 (<0.61) (referent)n1=25646.06 (42.97 to 49.15)41.15 (37.46 to 44.84)40.28 (35.84 to 44.72)39.95 (35.34 to 44.55)
 T2 (0.61–3.31)n2=2400.04 (−4.52 to 4.59)3.17 (−0.93 to 7.27)3.48 (−0.63 to 7.59)3.74 (−0.48 to 7.97)
 T3 (3.33–432.78)n3=2603.55 (−0.71 to 7.81)5.25 (1.19 to 9.32)5.93 (1.81 to 10.05)6.75 (1.49 to 12.02)
  • Values are estimated mean eGFR (95% CI) for referent tertile (T1), and estimated mean difference (95% CI) for the other tertiles (T2 and T3). There was a significant interaction between the highest urinary YKL-40 tertile and DGF (P=0.001) in unadjusted analyses.

  • a Donor variables used for adjustment: age (years), height (cm), weight (kg), black race, history of hypertension, history of diabetes, terminal serum creatinine, stroke as cause of death, and donation after circulatory determination of death status.

  • b Includes all variables listed above plus the following transport and recipient variables: cold ischemia time (hours), age (years), black race, gender, previous kidney transplant, diabetes as the cause of ESRD, number of human leukocyte antigen mismatches, body mass index (kg/m2), duration of dialysis before transplant (months), and panel reactive antibody (%).

  • c Includes all variables listed above plus log base 2–transformed donor urine NGAL.