Table 3.

Correlation of STAT activation levels and renal function in diabetic mice.

VariablesGlomeruliTubulointerstitium
P-STAT1+ CellsP-STAT3+ CellsP-STAT1+ CellsP-STAT3+ Cells
Pearson r (P Value)Pearson r (P Value)Pearson r (P Value)Pearson r (P Value)
KBWR, g/kg0.6055 (<0.01)0.7109 (<0.001)0.4717 (<0.05)0.5995 (<0.01)
UAC, μg/μmol0.5991 (<0.01)0.7149 (<0.001)0.7423 (<0.001)0.6723 (<0.01)
SCr, mmol/L0.7719 (<0.01)0.6587 (<0.01)0.6646 (<0.01)0.5635 (<0.05)
Glomerular area, μm20.9058 (<0.001)0.8097 (<0.001)N.D.N.D.
Mesangial area, % PAS0.6822 (<0.01)0.4587 (NS)N.D.N.D.
Fibrosis, % sirius red0.6608 (<0.01)0.6963 (<0.01)0.6185 (<0.01)0.7312 (<0.001)
T cells, CD3+0.7011 (<0.01)0.7621 (<0.001)0.6417 (<0.01)0.6082 (<0.01)
Macrophages, F4/80+0.6793 (<0.01)0.7954 (<0.001)0.6847 (<0.01)0.5603 (<0.02)
Kim-1 mRNA, a.u.0.6886 (<0.01)0.4226 (NS)0.5866 (<0.01)0.5592 (<0.02)
Ccl2 mRNA, a.u.0.8077 (<0.001)0.7229 (<0.001)0.7942 (<0.001)0.8257 (<0.001)
Ccl5 mRNA, a.u.0.7662 (<0.001)0.6541 (<0.01)0.6608 (<0.01)0.5621 (<0.02)
Tnfα mRNA, a.u.0.6726 (<0.01)0.7607 (<0.001)0.6502 (<0.01)0.6262 (<0.01)
Col I mRNA, a.u.0.7594 (<0.001)0.6959 (<0.01)0.7824 (<0.001)0.8384 (<0.001)
Fn mRNA, a.u.0.8198 (<0.001)0.7768 (<0.001)0.8386 (<0.001)0.7230 (<0.001)
Tgfβ mRNA, a.u.0.7893 (<0.001)0.6412 (<0.01)0.6869 (<0.01)0.6777 (<0.01)
  • Pearson correlation analysis between P-STAT1/3 immunostaining and renal variables in diabetic mice at 16 weeks of age. KBWR, kidney/body weight ratio; SCr, serum creatinine; N.D., not determined; a.u., arbitrary units.