Table 6.

Association of donor YKL-40 with graft failure, stratified by DGF status

Tertile of YKL-40 (Range [ng/ml])NGraft Failure Events (%)Graft Failure Rate Per 1000 Patient YearsHazard Ratio (95% CI)
UnadjustedAdjusted for Donor VariablesaAdjusted for Donor, Transport, and Recipient VariablesbAdjusted for Donor, Transport, Recipient Variables, and Donor NGALc
Recipients without DGF
 T1 (<0.61)n1=62042 (7)27.411.0 (referent)1.0 (referent)1.0 (referent)1.0 (referent)
 T2 (0.61–3.31)n2=58840 (7)27.571.02 (0.66 to 1.57)0.95 (0.63 to 1.43)1.00 (0.64 to 1.55)1.01 (0.63 to 1.61)
 T3 (3.33–432.78)n3=47131 (7)27.270.99 (0.61 to 1.61)1.00 (0.60 to 1.66)1.13 (0.65 to 1.95)1.15 (0.60 to 2.19)
Recipients with DGF
 T1 (<0.61)n1=25643 (17)76.621.0 (referent)1.0 (referent)1.0 (referent)1.0 (referent)
 T2 (0.61–3.31)n2=24044 (18)87.941.14 (0.74 to 1.74)1.06 (0.68 to 1.64)1.11 (0.71 to 1.74)1.07 (0.67 to 1.70)
 T3 (3.33–432.78)n3=26028 (11)46.030.61 (0.38 to 0.98)0.56 (0.34 to 0.94)0.57 (0.33 to 0.98)0.50 (0.27 to 0.94)
  • Donor AKI was defined as at least a doubling of serum creatinine from admission to the terminal value.

  • a Donor variables used for adjustment: age (years), height (cm), weight (kg), black race, history of hypertension, history of diabetes, terminal serum creatinine, stroke as cause of death, and donation after circulatory determination of death status.

  • b Includes all variables listed above plus the following transport and recipient variables: cold ischemia time (hours), age (years), black race, gender, previous kidney transplant, diabetes as the cause of ESRD, number of human leukocyte antigen mismatches, body mass index (kg/m2), duration of dialysis before transplant (months), and panel reactive antibody (%).

  • c Includes all variables listed above plus log base 2–transformed donor urine NGAL.