Table 2.

Hemodynamic factors

Hemodynamic FactorsRilonaceptPlaceboP Value
Baseline12 WkBaseline12 Wk
FMDBA, mm0.14±0.100.19±0.120.13±0.070.11±0.09<0.001
Baseline brachial artery diameter, mm3.99±0.803.97±0.743.94±0.684.13±0.590.36
Peak shear rate, s−1740±334716±311716±180710±2450.82
Brachial artery dilation to NTG, %17.9±10.418.3±4.817.6±8.013.5±5.20.09
Brachial artery dilation to NTG, mm0.66±0.330.70±0.230.65±0.250.54±0.190.07
Brachial SBP, mmHg130±18133±17141±18134±200.84
Brachial DBP, mmHg75±874±879±1275±90.74
cIMT, mm0.79±0.280.77±0.230.83±0.340.88±0.350.37
CR-PWV, cm/s959±129876±182987±2411013±1510.19
Carotid artery compliance, (mm/mmHg)×10−10.08±0.050.08±0.040.06±0.030.06±0.020.22
Carotid β-stiffness index, A.U.13.1±10.111.7±5.614.6±7.913.5±3.20.08
Carotid SBP, mmHg131±19128±24135±19128±260.98
  • Data are mean±SD. Brachial BPs were measured in the supine position during the tonometry assessment. CR-PWV, carotid artery compliance, carotid β-stiffness index, and carotid SBP were only measured in a subgroup of participants from the Denver site (see Concise Methods). P values are group effect from linear mixed-effects models (model also included 4-week and 8-week data) for all variables. NTG, nitroglycerin; DBP, diastolic BP; CR-PWV, carotid-radial pulse-wave velocity; A.U., arbitrary units.