Table 4.

Associations (HRs and 95% CIs) of FGF23 with first infection-related hospitalization stratified by kidney disease status (eGFR and urine ACR)

ModelQuartile 1 <53.34 RU/ml, n=786Quartile 2 =53.34–70.34 RU/ml, n=785Quartile 3 =70.35–99.33 RU/ml, n=786Quartile 4 >99.33 RU/ml, n=784Per Doubling of FGF23
eGFR≥60 ml/min per 1.73 m2
 Model 1Reference1.15 (0.96 to 1.38)1.18 (0.98 to 1.42)1.58 (1.29 to 1.94)1.19 (1.09 to 1.29)
 Model 2Reference1.05 (0.87 to 1.26)1.03 (0.85 to 1.25)1.25 (1.01 to 1.55)1.09 (0.99 to 1.19)
 Model 3Reference1.04 (0.87 to 1.25)0.99 (0.82 to 1.21)1.19 (0.96 to 1.49)1.06 (0.97 to 1.17)
eGFR<60 ml/min per 1.73 m2
 Model 1Reference1.34 (0.82 to 2.19)1.54 (0.96 to 2.46)2.14 (1.35 to 3.40)1.42 (1.26 to 1.59)
 Model 2Reference1.31 (0.80 to 2.16)1.31 (0.81 to 2.11)1.59 (0.98 to 2.58)1.26 (1.10 to 1.44)
 Model 3Reference1.35 (0.82 to 2.22)1.33 (0.82 to 2.16)1.62 (1.00 to 2.64)1.24 (1.08 to 1.42)
ACR≤30 mg/g
 Model 1Reference1.13 (0.94 to 1.36)1.26 (1.05 to 1.50)1.61 (1.32 to 1.95)1.23 (1.13 to 1.33)
 Model 2Reference1.06 (0.88 to 1.27)1.12 (0.93 to 1.35)1.28 (1.04 to 1.57)1.12 (1.03 to 1.23)
 Model 3Reference1.05 (0.88 to 1.26)1.09 (0.91 to 1.32)1.24 (1.00 to 1.53)1.11 (1.02 to 1.21)
ACR>30 mg/g
 Model 1Reference1.38 (0.88 to 2.16)1.24 (0.78 to 1.96)2.16 (1.42 to 3.30)1.37 (1.21 to 1.54)
 Model 2Reference1.22 (0.77 to 1.92)0.86 (0.53 to 1.40)1.33 (0.82 to 2.15)1.17 (1.00 to 1.36)
 Model 3Reference1.19 (0.75 to 1.88)0.82 (0.50 to 1.35)1.24 (0.76 to 2.02)1.13 (0.96 to 1.32)
  • Model 1: age, race, and sex. Model 2: model 1, smoking status, BMI, diabetes, CHD, CHF, eGFR (cystatin C equation), and urine ACR. Model 3: model 2, albumin, CRP, and IL-6. RU, relative unit.