Table 2.

Risk prediction models for incident post-KT dementia and AD among older (age ≥55) KT recipients

CharacteristicDementia HR (95% CI)AD HR (95% CI)
Recipient factors
Age (per 5 yr)1.50 (1.46 to 1.56)1.69 (1.59 to 1.80)
Women1.19 (1.09 to 1.29)
Race/ethnicity
  WhiteReference
  Black1.21 (1.09 to 1.33)
  Hispanic/Latino1.03 (0.90 to 1.18)
  Other/multiracial0.74 (0.61 to 0.91)
Body mass index, kg/m2
  <18.50.81 (0.47 to 1.40)0.48 (0.12 to 1.97)
  18.5–251.22 (1.09 to 1.36)1.32 (1.05 to 1.65)
  25–301.12 (1.01 to 1.24)1.11 (0.89 to 1.38)
  ≥30ReferenceReference
Diabetes1.64 (1.51 to 1.78)1.32 (1.11 to 1.56)
Previous transplant1.31 (0.89 to 1.92)
Years on dialysis (per 5 yr)1.09 (1.02 to 1.16)1.09 (0.97 to 1.22)
Education
  None1.66 (1.10 to 2.49)1.33 (0.57 to 3.13)
  Grade school (0–8)1.24 (1.01 to 1.53)1.26 (0.87 to 1.83)
  High school (9–12) or GED1.23 (1.06 to 1.44)1.15 (0.86 to 1.52)
  Attended college/technical school1.18 (0.99 to 1.40)0.90 (0.63 to 1.27)
  Associate or bachelor degreeReferenceReference
  Postcollege graduate degree1.17 (0.94 to 1.47)0.86 (0.54 to 1.35)
Transplant factors
ABO incompatible0.59 (0.24 to 1.42)
Year of KT (per 1 yr)0.91 (0.90 to 0.92)0.91 (0.89 to 0.93)
Donor factors
Donor type
  LiveReference
  Deceased standard criteria1.13 (1.01 to 1.27)
  ECD1.01 (0.87 to 1.18)
  DCD1.06 (0.85 to 1.33)
Race/ethnicity
  WhiteReference
  Black1.29 (1.01 to 1.64)
  Hispanic/Latino1.22 (0.95 to 1.55)
  Other/multiracial1.25 (0.81 to 1.91)
Hypertension1.04 (0.94 to 1.14)0.98 (0.81 to 1.19)
Diabetes1.03 (0.86 to 1.24)
HCV+1.23 (0.93 to 1.63)1.33 (0.77 to 2.30)
c-statistic0.660.69
  • All HRs are from a single adjusted competing risks survival model for the dementia and AD outcomes, separately. AD is a subtype of dementia; therefore, the AD cases are a subset of the dementia cases. Dementia and AD are ICD-reported diagnoses of dementia or AD. —, not included in model; GED, General Educational Development test; ECD, expanded criteria donor; DCD, donation after cardiac death; HCV+, hepatitis C virus-positive.