Table 4.

The impact of dementia and AD on death-censored graft loss and mortality stratified by age, race, sex, and diabetes status

Effect ModifierDeath-Censored Graft Loss HR (95% CI)Death with a Functioning Graft HR (95% CI)Mortality HR (95% CI)
Dementia
 Overall risk1.52 (1.39 to 1.68)2.74 (2.59 to 2.89)2.38 (2.26 to 2.49)
 Age, yr
  55–651.55 (1.35 to 1.79)2.90 (2.67 to 3.16)2.51 (2.32 to 2.70)
  ≥651.51 (1.32 to 1.72)2.78 (2.60 to 2.97)2.40 (2.25 to 2.55)
  P for interaction0.740.430.37
 Race
  Nonblack1.52 (1.34 to 1.71)2.82 (2.65 to 3.00)2.43 (2.30 to 2.57)
  Black1.53 (1.31 to 1.79)2.48 (2.23 to 2.76)2.22 (2.02 to 2.42)
  P for interaction0.920.040.08
 Sex
  Men1.50 (1.33 to 1.70)2.66 (2.48 to 2.85)2.32 (2.18 to 2.47)
  Women1.56 (1.34 to 1.81)2.86 (2.63 to 3.12)2.47 (2.29 to 2.66)
  P for interaction0.710.170.21
 Diabetes
  No1.36 (1.17 to 1.57)2.75 (2.55 to 2.97)2.37 (2.20 to 2.54)
  Yes1.66 (1.46 to 1.88)2.69 (2.50 to 2.89)2.35 (1.13 to 1.94)
  P for interaction0.040.660.89
AD
 Overall risk1.40 (1.15 to 1.70)2.49 (2.25 to 2.75)2.14 (1.95 to 2.36)
 Age, yr
  55–651.94 (1.46 to 2.58)2.90 (2.41 to 3.48)2.52 (2.13 to 2.98)
  ≥651.14 (0.86 to 1.49)2.50 (2.23 to 2.81)2.13 (1.90 to 2.38)
  P for interaction0.010.190.10
 Race
  Nonblack1.27 (0.99 to 1.63)2.47 (2.20 to 2.77)2.08 (1.87 to 2.32)
  Black1.61 (1.18 to 2.21)2.60 (2.13 to 3.17)2.33 (1.96 to 2.78)
  P for interaction0.240.660.24
 Sex
  Men1.36 (1.05 to 1.76)2.52 (2.22 to 2.86)2.20 (1.95 to 2.47)
  Women1.47 (1.09 to 1.99)2.48 (2.11 to 2.91)2.11 (1.82 to 2.45)
  P for interaction0.710.870.68
 Diabetes
  No1.32 (0.99 to 1.75)2.87 (2.50 to 3.28)2.38 (2.10 to 2.71)
  Yes1.48 (1.13 to 1.94)2.15 (1.86 to 2.49)1.93 (1.69 to 2.21)
  P for interaction0.550.010.03
  • All models are adjusted for the recipient, transplant, and donor factors listed in Table 2. The HR are estimated using a Cox proportional hazards model with time-varying dementia and AD. AD is a subtype of dementia; therefore, the AD cases are a subset of the dementia cases. Dementia and AD are ICD-reported diagnoses of dementia or AD.