Table 2.

Biomarker values in healthy controls and patients with IgAN at the time of diagnosis by native kidney biopsy and the time of renal transplantation

Serum BiomarkerHealthy ControlsIgANUnpaired t Test
Diagnosis (Dg)Transplantation (Tx)
No.303096
Serum biomarkeraAt Tx versus at Dg
 IgA, mg/ml2.20 (0.76)/2.093.16 (1.26)/2.902.99 (1.35)/2.68NS
  Unpaired t test versus controls<0.001 (t=−3.61)0.003 (t=3.07)
 Norm Gd-IgA, % HAA31.3 (9.1)/29.535.6 (14.5)/36.136.1 (12.6)/33.6NS
  Unpaired t test versus controlsNS0.05 (t=1.95)
 Total Gd-IgA, U/ml68.2 (26.0)/65.4111.1 (61.4)/97.9105.4 (54.2)/99.9NS
  Unpaired t test versus controls<0.001 (t=−3.52)<0.001 (t=3.62)
 IgG, mg/ml11.01 (2.64)/10.548.35 (2.19)/8.2910.16 (4.53)/9.430.04 (t=2.11)b
  Unpaired t test versus controls<0.001 (t=4.24)NS
 Norm IgG-autoAb, OD1.172 (0.242)/1.1951.795 (0.535)/1.6171.465 (0.447)/1.4980.001 (t=−3.37)c
  Unpaired t test versus controls<0.001 (t=−3.87)<0.001 (t=3.43)
 Total IgG-autoAb, U/ml25.60 (7.28)/24.3430.36 (12.59)/29.3330.55 (17.90)/27.04
  Unpaired t test versus controlsNS (0.08)NS (0.14)
 Norm IgA-autoAb, OD0.549 (0.234)/0.4580.715 (0.707)/0.3610.611 (0.580)/0.462
  Unpaired t test versus controlsNSNS
 Total IgA-autoAb, U/ml1.29 (0.91)/0.932.31 (2.41)/1.512.00 (2.28)/1.22
  Unpaired t test versus controls0.03 (t=−2.16)NS (0.10)
  • Norm, normalized; HAA, Helix aspersa agglutinin;

  • a Laboratory data shown as mean (SD)/median. Total Gd-IgA1 was calculated by multiplying HAA binding in percentage by the IgA concentration and is expressed in units per milliliter. Total IgG-autoAb was calculated by multiplying OD per 0.5 μg by the IgG concentration ×2 and is expressed in units per milliliter. Total IgA-autoAb was calculated by multiplying OD per 1 μg by the IgA concentration and is expressed in units per milliliter.

  • b NS by paired t test.

  • c P=0.001 (t=−4.36) by paired t test (30 at both date of diagnosis by native kidney biopsy and date of renal transplantation).