Table 1.

All SNPs associated with Gd-IgA1 with P<5×10−5 in discovery cohort

ChromosomeSNPRaw P ValueGCBonferroniGRAPHIC P Value
7ars10088972.35E−092.55E−090.0007455.49E−11
7ars7582634.34E−094.70E−090.0013771.90E−07
7ars132269136.55E−097.07E−090.0020771.19E−08
7ars47207243.91E−074.14E−070.12387.51E−09
17rs38037804.06E−064.26E−0610.982
8rs13446164.62E−064.85E−0610.510
6rs93834566.48E−066.80E−0610.755
11rs5193806.79E−067.12E−0610.598
11rs22798657.52E−067.88E−0610.0545
2rs2946577.89E−068.27E−0610.807
11rs115502991.03E−051.08E−0510.427
13rs15405101.13E−051.19E−0510.621
7ars21087801.46E−051.53E−0513.10E−06
7rs20601631.59E−051.66E−0510.00115
8rs6097601.73E−051.80E−0510.605
1rs121407601.82E−051.90E−0510.0227
  • GC, corrected for genomic control; Bonferroni, corrected stringently for 302,210 SNPs analyzed.

  • a SNPs at the C1GALT1 locus—only these SNPs also showed significant association with Gd-IgA1 in the GRAPHIC cohort.