Table 3.

Expression quantitative trait loci of SNPs associated with Gd-IgA131

SNPPositionGd-IgA1 P Value (Imputed)GRAPHIC Replication P ValueCell TypeeQTL P Value
rs1024630372864456.488E−103.906E−08LCL3.03884E−09
rs646365672441817.576E−091.458E−08LCL3.00367E−08
rs646365772442547.576E−091.455E−08LCL3.40312E−08
rs1322691372468467.576E−091.19E−08LCL3.8322E−08
rs1025150572544891.561E−081.721E−08LCL2.03717E−08
rs431898072564901.767E−081.426E−08LCL1.44846E−08
rs778027372504491.883E−080.00010165LCL3.11303E−09
rs288175572564392.022E−081.544E−07LCL1.07186E−07
rs288175672564392.022E−08N/ALCL1.46728E−07
rs1095204772895432.358E−082.003E−06LCL1.7149E−11
rs472072672254513.287E−081.68E−04LCL7.5698E−09
rs1177125972772153.691E−085.363E−06LCL1.14591E−11
rs472495872265537.369E−080.00017043LCL9.72937E−09
rs472072772266951.704E−072.569E−07LCL6.11804E−08
rs1270258872228063.597E−07N/ALCL7.84334E−07
rs5755200372231046.837E−075.952E−06LCL5.51448E−08
rs1177354571968788.911E−-070.00176318LCL1.59081E−06
rs104776372835691.034E−062.018E−06LCL3.64039E−11
  • Gd-IgA1 P values are imputed, except for rs13226913 which was directly genotyped. All of these SNPs are on the H1 haplotype and the allele associated with elevated Gd-IgA1 levels is associated with lower transcript levels in all cases. eQTL, expression quantitative trait loci; LCL, lymphoblastoid cell line; N/A, not available.