Table 2.

Association of haplotypes across C1GALT1 with Gd-IgA1 showing a similar effect of the H1 haplotype in both populations

CohortCHRSNP1SNP2HaplotypeFrequencyβP ValueBonferroni
White7rs4720724rs2190935GTCCGCa0.3190.3434.40E−113.96E−10
7rs4720724rs2190935ATCTAT0.2070.04980.3971
7rs4720724rs2190935AGCTAC0.17−0.3151.36E−061.22E−05
7rs4720724rs2190935AGTCAT0.134−0.2370.001530.01
7rs4720724rs2190935GGTCAT0.0479−0.190.1181
7rs4720724rs2190935AGTTAC0.0429−0.2580.04210.38
7rs4720724rs2190935ATCCGC0.01540.0580.781
7rs4720724rs2190935GTCTAT0.0120.3040.2141
7rs4720724rs2190935GTCCAC0.01130.2480.2651
Chinese7rs4720724rs2190935AGCTAC0.523−0.1840.0005920.005
7rs4720724rs2190935AGTCAT0.1620.07610.3071
7rs4720724rs2190935AGTTAC0.1620.180.01650.15
7rs4720724rs2190935GTCCGCa0.03590.5366.21E−055.59E−04
7rs4720724rs2190935GGTCAT0.02110.01190.9491
7rs4720724rs2190935ATTCAT0.0195−0.01890.9281
7rs4720724rs2190935GTTCGC0.0142−0.3920.1020.92
7rs4720724rs2190935ATCCGC0.0107−0.1480.5421
7rs4720724rs2190935AGCTAC0.010.2240.4311
  • P values represent the effect of testing each haploptype against all of the others. The commonest haplotype in the UK population is almost ten-fold less common in the Chinese population. SNPs defining this haplotype are rs4720724, rs758263, rs4263662, rs10259085, rs1008897, and rs2190935. Bonferroni, with correction for nine haplotypes tested.

  • a H1 haplotype.