Table 4.

Annual rate of eGFR decline by quartile of biomarker concentrations in VA-NEPHRON-D

VariableMean eGFR Decline in ml/min per 1.73 m2 per yr (SEM)P Value
TNFR-1, pg/ml0.01
 ≤3104−2.75 (0.18)
 3105–4186−3.33 (0.17)
 4187–5810−3.58 (0.18)
 ≥5811−3.33 (0.19)
TNFR-2, pg/ml<0.001
 ≤8182−2.52 (0.18)
 8183–10699−3.47 (0.17)
 10,700–13,813−3.68 (0.18)
 ≥13,814−3.39 (0.20)
KIM-1, pg/ml<0.001
 ≤235−2.00 (0.17)
 236–406−3.08 (0.17)
 407–709−3.34 (0.18)
 ≥710−5.46 (0.21)
  • Annual rate of decline derived from linear mixed models accounting for baseline eGFR, treatment arm, biomarker strata, and follow-up time.