Table 3.

Risk factors for ESRD according to unadjusted Cox regression analysis, a model adjusting for hereditary disease, and a multivariate model

VariableUnadjustedAdjusted for Hereditary DiseaseMultivariate Model
HR95% CIP ValueHR95% CIP ValueHR95% CIP Value
Characteristics at disease onset
 Age (reference ≥12 yr)
  >3 mo and <1 yr1.210.81 to 1.850.340.990.62 to 1.440.790.880.55 to 1.390.60
  ≥1 and <6 yr0.590.43 to 0.800.0010.570.41 to 0.780.0010.680.48 to 0.970.04
  ≥6 and <12 yr0.910.65 to 1.280.590.930.66 to 1.300.661.160.80 to 1.680.44
 Proteinuria (reference subnephrotic range)
  Nephrotic range1.670.94 to 2.960.081.731.00 to 3.000.051.330.74 to 2.410.34
 Serum albumin per 10-g/L increase1.01 0.88 to 1.160.900.93 0.81 to 1.080.360.860.72 to 1.020.09
 CKD (reference stage 1)
  Stage 21.341.00 to 1.790.051.250.93 to 1.680.141.170.88 to 1.570.28
  Stage 32.291.58 to 3.31<0.0012.191.48 to 3.250.0012.031.37 to 3.000.001
  Stage 46.213.92 to 9.82<0.0015.773.70 to 8.98<0.0015.103.12 to 8.34<0.001
Histopathology (reference MCGN)
 FSGS3.962.57 to 6.08<0.0013.612.34 to 5.56<0.0012.901.85 to 4.53<0.001
 DMS19.910.7 to 37.0<0.00113.27.01 to 25.0<0.00112.36.29 to 24.0<0.001
 MesPGN1.690.93 to 3.070.091.490.82 to 2.720.191.260.68 to 2.350.46
 Other3.591.87 to 6.870.0013.761.96 to 7.23<0.0013.421.75 to 6.670.003
 Unknown4.812.91 to 7.95<0.0013.882.34 to 6.44<0.0013.592.13 to 6.04<0.001
Cause of disease (reference sporadic)
 Familial1.180.79 to 1.750.421.100.73 to 1.660.66
 Genetic3.112.45 to 3.94<0.0012.391.83 to 3.13<0.001
Response to IIS (reference no remission)
 Partial remission0.340.18 to 0.630.0010.420.23 to 0.79<0.010.490.26 to 0.920.03
 Complete remission0.110.05 to 0.24<0.0010.140.06 to 0.31<0.0010.130.06 to 0.30<0.001
 Unknown0.820.63 to 1.070.140.820.63 to 1.080.160.760.57 to 1.010.06
  • Only covariates with significant contribution to the model are shown. HR, hazard ratio; MCGN, minimal-change glomerulopathy; DMS, diffuse mesangial sclerosis; MesPGN, mesangio-proliferative glomerulonephritis.