Table 4.

Multivariate correlates of dnDSA development: Subset treated with tacrolimus regime

Subset Treated with Tacrolimus RegimeDR dnDSA n=492, 19 EventsDQ dnDSA n=492, 34 EventsDR or DQ dnDSA n=492, 44 Events
HR (95% CI)P ValueHR (95% CI)P ValueHR (95% CI)P Value
Recipient age at transplant, yr0.95 (0.91 to 0.98)0.0020.95 (0.93 to 0.98)<0.0010.96 (0.94 to 0.97)<0.001
Nonadherence4.42 (1.74 to 11.41)0.0023.59 (1.73 to 7.43)0.0014.30 (2.29 to 8.08)<0.001
HLA-DRβ1/3/4/5 eplet mismatch/ten mismatches2.70 (1.64 to 4.53)<0.001
HLA-DQα11 eplet mismatch/ten mismatches2.24 (1.56 to 3.29)<0.001
HLA-DRβ1/3/4/5 + HLA-DQα11 eplet mismatch/ten mismatches1.34 (1.13 to 1.60)0.001