Table 2.

Multivariate correlates of dnDSA development: Total cohort

Total CohortDR dnDSA n=596, 29 EventsDQ dnDSA n=596, 51 EventsDR or DQ dnDSA n=596, 66 Events
HR (95% CI)P ValueHR (95% CI)P ValueHR (95% CI)P Value
Recipient age at transplant, yr0.97 (0.95 to 0.99)0.020.97 (0.95 to 0.98)0.0020.97 (0.96 to 0.99)0.001
Nonadherence3.07 (1.40 to 6.52)<0.013.11 (1.71 to 5.58)<0.0013.09 (1.83 to 5.15)<0.001
Cyclosporin versus tacrolimus2.14 (0.93 to 4.70)0.071.97 (1.06 to 3.52)0.032.28 (1.35 to 3.78)0.002
HLA-DRβ1/3/4/5 eplet mismatch/ten mismatches2.79 (1.84 to 4.27)<0.001
HLA-DQα11 eplet mismatch/ten mismatches2.00 (1.52 to 2.67)<0.001
HLA-DRβ1/3/4/5 + HLA-DQα11 eplet mismatch/ten mismatches1.37 (1.18 to 1.58)<0.001