Table 3.

Results from mixed effects regression models predicting eGFR and log UPCR slope

Sleep VariableModel 1aP ValueModel 2bP ValueModel 3cP Value
Regression coefficient (SEM) for eGFR slope, ml/min per 1.73 m2 per yr
Sleep duration, per 1 h lower, n=398−1.07 (0.52)0.04−1.27 (0.53)0.02−1.12 (0.50)0.02
Sleep fragmentation, per 1% higher, n=398−0.22 (0.07)0.002−0.23 (0.07)0.001−0.18 (0.07)<0.01
Sleep start time, per 1 h later, n=398−0.74 (0.44)0.10−0.89 (0.44)0.05−0.62 (0.41)0.13
PSQI, per one score point higher, n=3550.05 (0.17)0.780.00 (0.17)0.98−0.10 (0.16)0.54
ESS, per one score point higher, n=3860.11 (0.14)0.430.06 (0.14)0.640.06 (0.13)0.65
Regression coefficient (SEM) for slope of log-transformed UPCR, g/g per yr
Sleep duration, per 1 h lower, n=4290.09 (0.05)0.090.08 (0.05)0.070.06 (0.02)0.02
Sleep fragmentation, per 1% higher, n=4290.02 (0.01)0.0010.02 (0.01)0.0010.01 (0.00)<0.001
Sleep start time, per 1 h later, n=4290.06 (0.04)0.140.05 (0.04)0.160.01 (0.02)0.68
PSQI, per one score point higher, n=3850.01 (0.02)0.590.00 (0.01)0.770.01 (0.01)0.14
ESS, per one score point higher, n=4170.01 (0.01)0.440.01 (0.01)0.67−0.00 (0.01)0.76
• Sample sizes presented correspond to the final model.

• a Model 1: adjusted for clinical site, age, sex, and education.

• b Model 2: adjusted for variables in model 1 plus smoking, time-updated systolic BP, diabetes, BMI, cardiovascular disease, and urine sodium (millimoles per liter).

• c Model 3: In addition to the variables in model 2, eGFR slope models are adjusted for baseline log UPCR, and log UPCR models are adjusted for baseline eGFR.